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ESR10: Elham Adabi

Host: B6 Paul-Ehrlich-Institut / Supervisor: Prof. Dr. Christian Buchholz

Individual Project

Following CART T cell generation via single cell transcriptomics and barcoded antibody technology.

STACCATO Research

ESR10 will apply the use of antibodies in single cell RNA technology (AbSeq) to identify the subtypes and phenotypes of T cells that are preferentially transduced by lentiviral vectors specifically targeted to subtypes of human T cells.

Scientific Background

I obtained my Master Degree in medical biotechnology from Tehran University of Medical Sciences, Iran. During my masters’ thesis, we investigated a strategy to genetically engineer IL-2, in order to improve the efficacy and pharmacokinetic properties of this cytokine, as a passive cancer immunotherapy agent. Afterwards, as a research assistant in Endocrinology and Metabolism research institute in Tehran, I performed gene expression analysis to set novel biomarkers, and I also gained some experience in the maintenance of Zebrafish Lab. Then, I joined Hannover biomedical research school, where I focused on defining the role of gamma delta T-cells in EBV associated malignancies.