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Dr. Véronique Chotteau

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B5: Royal Institute of Technology, KTH

Position  & Role in STACCATO

Véronique Chotteau, Docent Principal Investigator of the Cell Technology group, Dept. Industrial Biotechnology, School of Engineering Sciences in Chemistry, Biotechnology, and Health, KTH (Royal Institute of Technology), Stockholm, Sweden. Main supervisor of ESR5, Co-supervisor of ESR2, ESR11. Leader of the WP4.

 

Background

Dr. Véronique Chotteau has more than 30 years of experience in mammalian cell culture including more than 10 years in biopharmaceutical industry (at Pharmacia Upjohn/Biovitrum, Stockholm, nowadays Swedish Orphan Biovitrum). She joined KTH in 2008, when she was offered to lead the animal cell cultivation activities, due to her expertise in cell culture and her industrial background. Since then, her group (2 post-doc, 5 PhD students, 2 master students, 3 staff’s) has focused on cell-based processes for production of biologics, high cell density perfusion and mathematical modelling, among others. Her group was the first to publish cell densities higher than 200 millions cells/mL in CHO cell perfusion process.

Key Publications

Hagrot, E, Hildur Oddsdóttir Æ, Forsgren A, Chotteau V, Novel column generation-based optimization approach for large poly-pathway kinetic model applied to CHO cell culture, accepted in Metabolic Engineering Communications

Zamani L, Lundqvist M, Zhang Y, Aberg M, Edfors F, Bidkhori G, Lindahl A, Mie A, Mardinoglu A, Field R, Turner R, Rockberg J, Chotteau V, High cell density perfusion culture has a maintained exoproteome and metabolome, 2018, Biotechnology Journal, 13:1800036. [DOI: 10.1002/biot.201800036].

Hagrot, E, Hildur Oddsdóttir Æ, Gonzalez Hosta J, Jacobsen EW, Chotteau V, ‘Poly-pathway model, a novel approach to simulate multiple metabolic states by reaction network-based model – Application to CHO cell culture’, 2017, Journal of Biotechnology 259:235-247. [DOI: 10.1016/j.jbiotec.2017.05.026].

Zhang Y, Stobbe, P, Orrego, C.S, Chotteau V, ‘Very high cell density perfusion of CHO cells anchored in a non-woven matrix-based bioreactor’, 2015, J. Biotechnology 213:28-41. [DOI: 10.1016/j.jbiotec.2015.07.006].

Hildur Oddsdóttir Æ, Hagrot E, Chotteau V, Forsgren A, On Dynamically Generating Relevant Elementary Flux Modes in a Metabolic Network using Optimization, 2015, Journal of Mathematical Biology 71:903-920. [DOI: 10.1007/s00285-014-0844-1].

Clincke M-F, Mölleryd C, Zhang Y, Lindskog E, Walsh K, Chotteau V, Very High Density of CHO Cells in Perfusion by ATF or TFF in WAVE Bioreactor™ – Part I. Effect of the Cell Density on the Process, 2013, Biotechnology Progress, 29:754-767. [DOI:10.1002/btpr.1704].

Clincke M-F, Mölleryd C, Samani PK, Lindskog E, Fäldt E, Walsh K, Chotteau V, Very High Density of CHO Cells in Perfusion by ATF or TFF in WAVE Bioreactor™ – Part II: Applications for Antibody Production and Cryopreservation, 2013, Biotechnology Progress, 29:768-777. [DOI: 10.1002/btpr.1703].