One open position at BD Research Centre Ireland
Fully funded Horizon 2020 Marie Sklodowska-Curie PhD position within the European Industrial Doctorate project STACCATO aimed at enhancing upstream biopharmaceutical manufacturing process development through single cell analysis.
The successful candidate will be primarily located at BDs research centre of excellence in Limerick, Ireland with University College Dublin acting as the PhD awarding body. As part of the collaborative STACCATO agreement, the successful candidate will have two four-month secondments with other members of the STACCATO consortium.
The project aims to develop BD Rhapsody gene panels to monitor cellular behaviour during biopharmaceutical production. The BD Rhapsody workflow incorporating BDs highly accurate molecular indexing technology enables the measurement of both protein and gene expression in the same cell. Here we will use it to monitor and elucidate pathways and biomarkers associated to sample phenotype and cellular behaviour in cell culture processes in biopharmaceutical production development. Through collaboration, we will develop and validate Rhapsody primer panels targeting pathways of interest in selected cell lines and primary cells with a view to improving their performance as biopharmaceutical factories.
Essential Background
- An honours BSc or MSc in biology, biotechnology, biochemistry or a related discipline that facilitates their enrolment in a PhD program at UCD.
- Knowledge of molecular biology and transcriptomics and the application of these technologies in biopharmaceutical process development.
- Fluency in written and spoken English.
Desirable Background
- Hands-on experience with cell line and primary cell cultures. In-depth knowledge in transcriptome analysis; experienced in flow cytometry and cell sorting.
- Practical experience with mammalian cell culture and handling of mammalian cells.
- Experience of working in multidisciplinary research teams.
Contact
Dr Siobhán Cashman, [email protected]
