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European Union’s Rules for applying

At the time of recruitment, the applicants should be in the first four years (full-time equivalent research
experience) of their research careers and have not been awarded a doctoral degree.

Mobility rule: At the time of recruitment, applicants should not have resided or carried out main activity
(studies, work, etc.) in the country of the host for more than 12 months in the 3 years prior to the
recruitment date.

Language skills: Applicants must demonstrate that their ability to understand and express themselves
in both written and spoken English is sufficiently high.

What we offer

The successful candidates will join a international scientific network of high profile industry and academic
partners. All fellows will benefit from intersectorial secondments, individual and networkwide training modules,
including transferable skills courses. Furthermore, each ESR will be supervised by a Industry-Academia
supervisory team consisting of at least one supervisor from each field.

ESR 1:

Single cell analysis for Biopharmaceutical Manufacturing

Expected results: Suite of Rhapsody scRNASeq primer panels for characterisation.

Host: Becton Dickinson Research Centre Ireland ltd (BD), Ireland

Main Supervisor: Dr. Sean Hanniffy

ESR 2:

Identification of Mitochondrial DNA mutations in single cells for Biopharmaceutical Manufacturing

Expected results: A robust single cell mtDNA sequencing method for biopharmaceutical cells and application of the information to improve cell line development approaches.

Host: National Institute for Bioprocessing Research and Training (NIBRT), Ireland

Main Supervisor: Prof. Niall Barron

ESR 3:

Single cell proteomics to analyse functional heterogeneity during biopharmaceutical manufacturing

Expected results: Optimised platform for proteomic sample preparation from single cells focused on maximising recovery of the proteome and LCMS based methods.

Host: National Institute for Bioprocessing Research and Training (NIBRT), Ireland

Main Supervisor: Prof. Jonathan Bones

ESR 4:

Improving oncolytic adenovirus production in host cell utilising single cell analysis technology

Expected results: Optimised scalable production method for oncolytic adenovirus vectors. Understanding of factors influencing oncolysis and other outcomes of TILT-123 in tumour and normal cells.

Host: TILT Biotherapeutics Ltd. (TILT), Finland

Main Supervisor: Dr. Suvi Sorsa

ESR 5:

Developing high cell density perfusion culture media through single cell analysis

Expected results: A novel approach for HCDP medium development and in particular for HCDP.

Host: Royal Institute of Technology. (KTH), Sweden

Main Supervisor: Dr. Véronique Chotteau

ESR 6:

Understanding CHO cell heterogeneity to enable increased production of recombinant therapeutic proteins

Expected results: Understanding the production demands of producing a range of therapeutic proteins in CHO cells for. Increasing the understanding the origins of glycosylation heterogeneity for a range of therapeutic proteins. Creation of new high performance CHO cell lines generated using genetic engineering.

Host: National Institute for Bioprocessing Research and Training (NIBRT), Ireland

Main Supervisor: Dr. Colin Clarke

ESR 7:

Improving productions of influenzia VLP-based vaccines in insect cells using single cell analysis

Expected results: (a) Increased knowledge on the underlying biological mechanisms of insect cell factories essential for efficient production of influence VLPs; (b) Improved cell specific productivity by rational genetic engineering of baculovirus and/or insect cells; (c) Establishment of a continuous process mode for influenza VLP vaccine production in stirred tank bioreactors.

Host: iBET (iBET), Portugal

Main Supervisor: Prof. Paula Alves

ESR 8:

Combining single-cell analysis with systems biology to fine-tune production of rAAV vectors in insect cells

Expected results: (a) Increased knowledge on the underlying biological mechanisms for efficient rAAV vector production; (b) A framework integrating single-cell analysis with systems biology tools (metabolomics and fluxomics) for process design; (c) Hybrid bioprocessing system for production of rAAV vectors using rational refeed strategies.

Host: iBET (iBET), Portugal

Main Supervisor: Prof. Paula Alves

ESR 9:

Determining the molecular impact of the manufacuring process for the phenotype of CAR T cells

Expected results: Molecular insights into the CAR T cell production process.

Host: Paul-Ehrlich Institut (PEI), Germany

Main Supervisor: Prof. Christian Buchholz

ESR 10:

Molecular impact of T-cell targeted gene transfer under minimal manipulation conditions

Expected results: Understanding the impact of the gene delivery process on the properties of CAR T cells.

Host: Paul-Ehrlich Institut (PEI), Germany

Main Supervisor: Prof. Christian Buchholz

ESR 11:

Development of methods to control differentiation of stem cells in a 3D cell culture system based on spider silk

Expected results: A general protocol for culture and differentiation of stem cells integrated in a 3D silk scaffold format suitable for a bioreactor with support of scRNASeq and proteomics

Host: Royale Institute of Technology (KTH), Sweden

Main Supervisor: Prof. My Hedhammar

More information you can find under STACCATO ESR Postions.